How I diagnose and manage individuals at risk for inherited myeloid malignancies

שנת פרסום ראשונה: אוקטובר 2016
שנת עדכון:
מפרסם: blood journal

Astute clinicians have reported familial clustering of myelodysplastic syndrome (MDS) and acute leukemia (AL; MDS/AL) for decades.1 These physicians often described phenotypic features that are now known to be associated with specific genetically defined hereditary myeloid malignancy syndromes (HMMSs).2Why, then, is the diagnosis of HMMS only now starting to be considered in the evaluation of the average adult patient with MDS/AL?