Primary abnormalities of the erythrocyte membrane lead to a variety of clinical syndromes, including hereditary spherocytosis (HS), hereditary elliptocytosis, and related disorders.1 Clinical and laboratory manifestations, as well as associated molecular defects, of these disorders vary widely. Abnormalities of erythrocyte shape on peripheral blood smear often provide clues to the underlying pathobiology and clinical diagnosis of the underlying disorder

Pediatr Clin N Am 60 (2013) 1349–1362 http://dx.doi.org/10.1016/j.pcl.2013.09.001