Type 2B von Willebrand disease (VWD) is an inherited bleeding disorder caused by changes in von Willebrand factor (VWF) that enhance binding of VWF to GPIb on platelets.
BLOOD, 22 MARCH 2018 | VOLUME 131, NUMBER 12
Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction.
BLOOD, 22 FEBRUARY 2018 | VOLUME 131, NUMBER 8
Situations that ordinarily necessitate consideration of anticoagulation, such as arterial and venous thrombotic events and prevention of stroke in atrial fibrillation, become challenging in patients with inherited bleeding disorders such as hemophilia A, hemophilia B, and von Willebrand disease.
BLOOD, 14 JULY 2016 x VOLUME 128, NUMBER 2
Acquired thrombotic thrombocytopenic purpura (TTP) is characterized by thrombocytopenia and microangiopathic hemolytic anemia (MAHA) without an obvious
cause, and may include fever, mild renal failure, and neurologic deficits.
BLOOD, 18 JUNE 2015 x VOLUME 125, NUMBER 25
Type 2 von Willebrand disease (VWD) includes a wide range of qualitative abnormalities of von Willebrand factor structure and function resulting in a variable
bleeding tendency.
BLOOD, 5 FEBRUARY 2015 x VOLUME 125, NUMBER 6
This is a single guideline replacing two separate guidelines on diagnosis and management respectively, published in 2004 (Laffan et al, 2004; Pasi et al, 2004). Where there has been no significant change in understanding or practice, the reader is referred to the earlier guidelines.
British Journal of Haematology, 2014, 167, 453–465 doi:10.1111/bjh.13064
A United Kingdom Haemophilia Centre Doctors’ Organization guideline on behalf of the British Committee for Standards in Haematology
British Journal of Haematology, 2014, 167, 304–326, doi: 10.1111/bjh.13058
KEY POINTS
Pediatr Clin N Am 60 (2013) 1407–1417 http://dx.doi.org/10.1016/j.pcl.2013.08.003
Bleeding disorders are broadly classified into primary and secondary hemostatic defects
(Fig. 1).
Pediatr Clin N Am 60 (2013) 1419–1441, http://dx.doi.org/10.1016/j.pcl.2013.09.002
Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP)
are 2 rare clinical entities.
Pediatr Clin N Am 60 (2013) 1513–1526, http://dx.doi.org/10.1016/j.pcl.2013.08.007
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