How I treat and manage strokes in sickle cell disease

תאריך: 28/05/2015

Neurologic complications are a major cause of morbidity and mortality in sickle
cell disease (SCD). In children with sickle cell anemia, routine use of transcranial
Doppler screening, coupled with regular blood transfusion therapy, has decreased
the prevalence of overt stroke from ∼11% to 1%.  (Blood. 2015;125(22):3401-3410)

BLOOD, 28 MAY 2015 x VOLUME 125, NUMBER 22

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Sickle Cell Disease in Childhood

תאריך: 31/12/2013

KEY POINTS

  • SCD affects the entire body, beginning in very early infancy, and a multidisciplinary team is needed to care for children with SCD.
  • Some forms of SCD-related morbidity, such as overt stroke, are decreasing owing to prognostic and therapeutic advancements.
  • Primary prevention of organ injury is an important focus of current research.
  • Almost all children born with SCD in developed nations now survive to adulthood, but the transition to adult medical care is a high-risk period for death.

Pediatr Clin N Am 60 (2013) 1363–1381 http://dx.doi.org/10.1016/j.pcl.2013.09.006

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